Dalton E Jane, Heinrichs R Walter
Department of Psychology, York University, Toronto, ON, Canada.
Neuropsychology. 2005 Mar;19(2):152-8. doi: 10.1037/0894-4105.19.2.152.
The published literature on depression in multiple sclerosis (MS) is reviewed quantitatively. The authors report mean effect sizes for 20 studies comparing depression scores of MS patients with those of healthy participants (d=1.07) and 21 studies comparing depression scores of MS patients with those of patients who have other chronic conditions (d=-0.14). The confidence interval for the mean overall MS-medical comparison included 0. However, subgroups of patients with chronic fatigue and spinal-neuromuscular conditions were more and less depressed than MS patients, respectively. Results indicate that a majority of MS patients with mild to moderate disability levels are distinguishable from healthy people in terms of depressive symptoms. However, the depression-disease link is complex and not specific to this form of demyelinating illness.
对已发表的关于多发性硬化症（MS）患者抑郁症的文献进行了定量综述。作者报告了20项比较MS患者与健康参与者抑郁评分的研究的平均效应量（d = 1.07），以及21项比较MS患者与患有其他慢性病患者抑郁评分的研究的平均效应量（d = -0.14）。MS与医学状况总体比较的平均效应量的置信区间包含0。然而，患有慢性疲劳和脊髓神经肌肉疾病的患者亚组分别比MS患者更抑郁和更不抑郁。结果表明，大多数轻度至中度残疾水平的MS患者在抑郁症状方面与健康人有区别。然而，抑郁与疾病之间的联系很复杂，并非这种脱髓鞘疾病所特有。
