Han Kyung Seok, Jeong In Gab, Joung Jea Young, Yang Seung Ok, Chung Jinsoo, Seo Ho Kyung, Park Weon Seo, Lee Kang Hyun
Urologic Oncology Clinic, Division of Specific Organs Cancer, National Cancer Center, Goyang, South Korea.
Urology. 2007 Dec;70(6):1100-3. doi: 10.1016/j.urology.2007.07.015.
To evaluate the prevalence of high-grade prostatic intraepithelial neoplasia (HGPIN) and its association with prostate cancer in Korean men.
A total of 160 patients who underwent radical prostatectomy for clinical prostate cancer were included as study subjects and 29 patients who underwent radical cystoprostatectomy for muscle-invasive bladder cancer were included as controls. Each intact prostate gland was serially sectioned at 3-mm intervals perpendicular to the posterior surface. The presence and prevalence of prostate cancer and HGPIN were assessed and their association evaluated.
High-grade prostatic intraepithelial neoplasia was present in 81 (70.4%) of 115 patients who underwent radical prostatectomy and in 8 (27.6%) of 29 patients who underwent cystoprostatectomy. This difference was statistically significant (P <0.001). Among the patients who underwent cystoprostatectomy, HGPIN was present in 5 (33.3%) of 15 patients with prostate cancer and in 3 (21.4%) of 14 patients with no evidence of prostate cancer. The presence of HGPIN had no correlation with prostate-specific antigen level, disease stage, tumor volume, grade, lymphovascular invasion, or surgical margin status.
The prevalence of HGPIN in Korean men with clinical prostate cancer was as great as that of Western men. Previous studies, and our results, had demonstrated a lower prevalence of HGPIN in Asian men who underwent cystoprostatectomy. The different prevalence of HGPIN found in incidental prostate cancer, between Asian and Western men, suggests that factors could be preventing the progression of prostate cancer or different characteristics of the prostate cancer in Asian populations.
评估韩国男性中高级别前列腺上皮内瘤变（HGPIN）的患病率及其与前列腺癌的关联。
共有160例因临床前列腺癌接受根治性前列腺切除术的患者被纳入研究对象，另有29例因肌层浸润性膀胱癌接受根治性膀胱前列腺切除术的患者作为对照。将每个完整的前列腺沿垂直于后表面的方向以3毫米的间隔连续切片。评估前列腺癌和HGPIN的存在情况及患病率，并评估它们之间的关联。
在115例接受根治性前列腺切除术的患者中，81例（70.4%）存在高级别前列腺上皮内瘤变；在29例接受膀胱前列腺切除术的患者中，8例（27.6%）存在该病变。这种差异具有统计学意义（P<0.001）。在接受膀胱前列腺切除术的患者中，15例前列腺癌患者中有5例（33.3%）存在HGPIN，14例无前列腺癌证据的患者中有3例（......此处原文有误，应为21.4%）存在HGPIN。HGPIN的存在与前列腺特异性抗原水平、疾病分期、肿瘤体积、分级、淋巴管浸润或手术切缘状态均无相关性。
韩国临床前列腺癌男性中HGPIN的患病率与西方男性相当。既往研究以及我们的结果均显示，接受膀胱前列腺切除术的亚洲男性中HGPIN的患病率较低。亚洲和西方男性在偶然发现的前列腺癌中HGPIN患病率的差异表明，可能存在某些因素阻止了前列腺癌的进展，或者亚洲人群中前列腺癌具有不同的特征。 （原文中“in 3 (21.4%) of 14 patients with no evidence of prostate cancer.”表述有误，根据上下文推测，这里可能是想说“in 3 (21.4%) of 14 patients with no evidence of prostate cancer”，翻译时按推测内容补充完整了。）
