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高级别前列腺上皮内瘤变

High-grade prostatic intraepithelial neoplasia.

作者信息

Klink Joseph C, Miocinovic Ranko, Magi Galluzzi Cristina, Klein Eric A

机构信息

Glickman Urologic and Kidney Institute, Cleveland, Ohio, USA.

出版信息

Korean J Urol. 2012 May;53(5):297-303. doi: 10.4111/kju.2012.53.5.297. Epub 2012 May 18.

DOI:10.4111/kju.2012.53.5.297
PMID:22670187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3364467/
Abstract

High-grade prostatic intraepithelial neoplasia (HGPIN) has been established as a precursor to prostatic adenocarcinoma. HGPIN shares many morphological, genetic, and molecular signatures with prostate cancer. Its predictive value for the development of future adenocarcinoma during the prostate-specific antigen screening era has decreased, mostly owing to the increase in prostate biopsy cores. Nevertheless, a literature review supports that large-volume HGPIN and multiple cores of involvement at the initial biopsy should prompt a repeat biopsy of the prostate within 1 year. No treatment is recommended for HGPIN to slow its progression to cancer.

摘要

高级别前列腺上皮内瘤变（HGPIN）已被确认为前列腺腺癌的前驱病变。HGPIN与前列腺癌具有许多形态学、遗传学和分子特征。在前列腺特异性抗原筛查时代，其对未来腺癌发生的预测价值有所下降，主要是由于前列腺活检芯数的增加。然而，文献综述支持，初次活检时发现的大量HGPIN和多个活检芯受累应促使在1年内重复进行前列腺活检。不建议对HGPIN进行治疗以减缓其向癌症的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ae/3364467/5c27aa8b43f1/kju-53-297-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ae/3364467/170a2dbae575/kju-53-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ae/3364467/5c27aa8b43f1/kju-53-297-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ae/3364467/170a2dbae575/kju-53-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2ae/3364467/5c27aa8b43f1/kju-53-297-g002.jpg

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1
High-grade prostatic intraepithelial neoplasia.高级别前列腺上皮内瘤变
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本文引用的文献

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Precursors of prostate cancer.前列腺癌的前体。
Histopathology. 2012 Jan;60(1):4-27. doi: 10.1111/j.1365-2559.2011.04007.x.
2
Using a saturation biopsy scheme increases cancer detection during repeat biopsy in men with high-grade prostatic intra-epithelial neoplasia.在高级别前列腺上皮内瘤变男性中，使用饱和活检方案可增加重复活检时的癌症检出率。
Urology. 2011 Nov;78(5):1115-9. doi: 10.1016/j.urology.2011.04.067.
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Diagnosis of isolated high-grade prostatic intra-epithelial neoplasia: proposal of a nomogram for the prediction of cancer detection at saturation re-biopsy.
高尔基体磷蛋白3（GOLPH3）和Y盒结合蛋白1（YB-1）是与前列腺癌预后不良相关的新型标志物。
World J Oncol. 2015 Dec;6(6):473-484. doi: 10.14740/wjon952w. Epub 2015 Dec 31.
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VPAC1 Targeted Cu-TP3805 kit preparation and its evaluation.VPAC1靶向铜-TP3805试剂盒的制备及其评估。
Nucl Med Biol. 2017 Aug;51:55-61. doi: 10.1016/j.nucmedbio.2017.04.007. Epub 2017 May 3.
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Clinical variability and molecular heterogeneity in prostate cancer.前列腺癌的临床变异性与分子异质性
Asian J Androl. 2016 Jul-Aug;18(4):543-8. doi: 10.4103/1008-682X.178852.
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Risk perception and psychological morbidity in men at elevated risk for prostate cancer.前列腺癌高危男性的风险认知与心理疾病
Curr Oncol. 2015 Dec;22(6):e462-9. doi: 10.3747/co.22.2679.
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PLoS One. 2015 Nov 6;10(11):e0142373. doi: 10.1371/journal.pone.0142373. eCollection 2015.
孤立性高级别前列腺上皮内瘤变的诊断：预测饱和重活检时检出癌症的列线图的提出。
BJU Int. 2012 May;109(9):1329-34. doi: 10.1111/j.1464-410X.2011.10532.x. Epub 2011 Sep 2.
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BJU Int. 2011 Nov;108(9):1394-401. doi: 10.1111/j.1464-410X.2011.010413.x. Epub 2011 Aug 26.
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J Clin Pathol. 2011 Aug;64(8):683-8. doi: 10.1136/jclinpath-2011-200083. Epub 2011 Jun 8.
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J Clin Oncol. 2011 Jun 10;29(17):2386-90. doi: 10.1200/JCO.2010.32.0994. Epub 2011 May 2.
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Prostate Cancer Prostatic Dis. 2011 Jun;14(2):173-6. doi: 10.1038/pcan.2011.3. Epub 2011 Mar 1.
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EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease.EAU 前列腺癌指南。第 1 部分：局限性疾病的筛查、诊断和治疗。
Eur Urol. 2011 Jan;59(1):61-71. doi: 10.1016/j.eururo.2010.10.039. Epub 2010 Oct 28.
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NCCN clinical practice guidelines in oncology: prostate cancer early detection.美国国立综合癌症网络（NCCN）肿瘤学临床实践指南：前列腺癌早期检测
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