Huang J Q, Lu X H, Mai C R
Department of Medicine, Peking Union Medical College Hospital, Beijing.
Zhonghua Nei Ke Za Zhi. 1991 Nov;30(11):699-702, 731.
We used a catheter passing through the papilla duodeni under the view of endoscope, with persistent perfusion system and transducer, to measure the pressure and contraction frequency of sphincter of Oddi (SO) in 10 healthy persons and 20 patients. Meanwhile, we compared the effect of Buscopan, Nitrostat and Vitamin K3 on the pressure and contraction frequency (CF). SO basal pressure (BP) in healthy group was 5.21 +/- 1.61 kPa (mean +/- s), SO peak pressure (PP) 8.21 +/- 1.34 kPa and CF 6.14 waves/min. In the group of peripapillary fistula, SO pressure decreased significantly and CF slowed down greatly. In comparison with the healthy group, SO pressure and CF in the group of gallbladder stone, choledocholithiasis and pancreatic diseases did not show any change of statistic significance. Intravenous injection of Buscopan could decrease SO peak pressure and BP remarkably. Sublingual administration of Nitrostat and intramuscular injection of Vit K3 could reduce SO PP markedly, SO BP didn't change statistically. It was also showed that spheric and semi-spheric papillae had higher pressure than the flat ones (P less than 0.001).
我们在内窥镜直视下，使用一根穿过十二指肠乳头的导管，并配备持续灌注系统和传感器，对10名健康人和20名患者的Oddi括约肌（SO）压力及收缩频率进行测量。同时，比较了东莨菪碱、硝酸甘油和维生素K3对压力及收缩频率（CF）的影响。健康组SO基础压力（BP）为5.21±1.61千帕（均值±标准差），SO峰值压力（PP）为8.21±1.34千帕，CF为6.14次/分钟。在乳头周围瘘组，SO压力显著降低，CF明显减慢。与健康组相比，胆囊结石组、胆总管结石组和胰腺疾病组的SO压力和CF无统计学意义的变化。静脉注射东莨菪碱可显著降低SO峰值压力和BP。舌下含服硝酸甘油和肌肉注射维生素K3可显著降低SO PP，SO BP无统计学变化。还显示，球形和半球形乳头的压力高于扁平乳头（P<0.001）。
