Zhang J, Meng J M, Pang S Q
Department of Neurology, Xuanwu Hospital, Capital Institute of Medicine, Beijing.
Zhonghua Nei Ke Za Zhi. 1991 Dec;30(12):755-7, 789-90.
Several erythrocyte biophysical properties (erythrocyte deformability, erythrocyte aggregation and erythrocyte electrophoretic mobility) were investigated in patients with cerebral infarction and in individuals with risk factors of stroke (RFS population; RFSP). Blood viscosity, plasma viscosity, hematocrit, plasma fibrinogen level and yield shear stress (YSS) were also tested. In comparison with the results in a control group, erythrocyte deformability (erythrocyte length under a certain constant shear stress and erythrocyte filterability) was less in both the patient group and the group of RFSP and there is an accompanying increase of erythrocyte aggregation. Blood viscosity and fibrinogen level were higher in the patient groups. There was no correlation between erythrocyte deformability and other hemorheological parameters. Our results suggest that significant alteration of erythrocyte biophysical properties may be implicated in the pathogenesis of ischemic stroke. These abnormalities are associated with some of the risk factors of stroke such as hypertension, atherosclerosis and cardiovascular disorders.
对脑梗死患者和有中风危险因素的个体（中风危险因素人群；RFSP）的几种红细胞生物物理特性（红细胞变形性、红细胞聚集性和红细胞电泳迁移率）进行了研究。还检测了血液粘度、血浆粘度、血细胞比容、血浆纤维蛋白原水平和屈服剪切应力（YSS）。与对照组结果相比，患者组和RFSP组的红细胞变形性（在一定恒定剪切应力下的红细胞长度和红细胞滤过率）均较低，且红细胞聚集性随之增加。患者组的血液粘度和纤维蛋白原水平较高。红细胞变形性与其他血液流变学参数之间无相关性。我们的结果表明，红细胞生物物理特性的显著改变可能与缺血性中风的发病机制有关。这些异常与中风的一些危险因素如高血压、动脉粥样硬化和心血管疾病相关。
