Totsimon Kinga, Nagy Alexandra, Sandor Barbara, Biro Katalin, Csatho Arpad, Szapary Laszlo, Toth Kalman, Marton Zsolt, Kenyeres Peter
1st Department of Medicine, University of Pecs, Medical School, Hungary.
Department of Behavioral Sciences, University of Pecs, Medical School, Hungary.
Clin Hemorheol Microcirc. 2016 Nov 4;64(1):55-63. doi: 10.3233/CH-162043.
Carotid artery stenosis (CAS) is not only an important risk factor of cerebrovascular events but it can also indicate generalized atherosclerosis. Hemorheological parameters are altered in CAS and in chronic cerebrovascular disorders as well, but it is controversial if hemorheological parameters could be markers of stenosis or atherosclerosis.
107 patients were investigated, 40% of them had stroke or TIA in case history and 48% had CAS. Routine lab parameters were determined and hemorheological variables were measured: hematocrit, plasma viscosity, whole blood viscosity, red blood cell aggregation, and deformability.
In the stenotic group whole blood viscosity and red blood cell aggregation were deteriorated (p < 0.05). Whole blood and plasma viscosity were higher and red blood cell deformability was lower in the symptomatic group (p < 0.05). Plasma viscosity and red blood cell deformability were altered in the evolving atherosclerosis group and the CAS groups compared to patients having no signs of stenosis (p < 0.05), but there was no difference among the CAS groups.
Although hemorheological parameters are impaired both in CAS and chronic cerebrovascular disorders, the severity of stenosis cannot be detected based on hemorheological parameters. Our investigation suggests that alteration of hemorheological parameters could indicate carotid atherosclerosis.
颈动脉狭窄（CAS）不仅是脑血管事件的重要危险因素，还可提示全身性动脉粥样硬化。血液流变学参数在CAS以及慢性脑血管疾病中均会发生改变，但血液流变学参数是否可作为狭窄或动脉粥样硬化的标志物仍存在争议。
对107例患者进行了研究，其中40%有中风或短暂性脑缺血发作病史，48%有CAS。测定常规实验室参数并测量血液流变学变量：血细胞比容、血浆黏度、全血黏度、红细胞聚集性和变形性。
在狭窄组中，全血黏度和红细胞聚集性恶化（p<0.05）。有症状组的全血和血浆黏度较高，红细胞变形性较低（p<0.05）。与无狭窄迹象的患者相比，在动脉粥样硬化进展组和CAS组中血浆黏度和红细胞变形性发生了改变（p<0.05），但CAS组之间无差异。
虽然血液流变学参数在CAS和慢性脑血管疾病中均受损，但无法根据血液流变学参数检测狭窄的严重程度。我们的研究表明，血液流变学参数的改变可能提示颈动脉粥样硬化。
