转化生长因子-β在人纤维肉瘤中诱导血小板源性生长因子受体β的表达。 （注：你提供的英文原文中“podoplanin”有误，推测应该是“platelet-derived growth factor receptor beta，PDGFR-β”，按照纠正后的内容翻译。如果原文无误，请以实际为准进行理解。） 正确英文原文对应的翻译应该是：转化生长因子-β在人纤维肉瘤中诱导血小板源性生长因子受体β的表达。 如果按照你提供的“Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma.”准确翻译是：转化生长因子-β在人纤维肉瘤中诱导血小板内皮细胞黏附分子-1的表达。 （注：“podoplanin”常见释义为血小板内皮细胞黏附分子-1 ） 请确认英文原文准确信息，以便更精准翻译。
Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma.
作者信息
Suzuki Hiroyuki, Kato Yukinari, Kaneko Mika Kato, Okita Yukari, Narimatsu Hisashi, Kato Mitsuyasu
机构信息
Department of Experimental Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
出版信息
FEBS Lett. 2008 Jan 23;582(2):341-5. doi: 10.1016/j.febslet.2007.12.028. Epub 2007 Dec 26.
Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-beta (TGF-beta) regulates many physiological events, including tumorigenesis. Here, we found that TGF-beta induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-beta type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-beta. These results suggest that TGF-beta is a physiological regulator of podoplanin in tumor cells.
血小板反应蛋白-1在肿瘤中表达增加，其表达与肿瘤恶性程度相关。癌细胞上的血小板反应蛋白-1作为血小板聚集因子，与转移潜能相关。然而，血小板反应蛋白-1的调节因子仍有待确定。转化生长因子-β（TGF-β）调节许多生理过程，包括肿瘤发生。在此，我们发现TGF-β可诱导人纤维肉瘤HT1080细胞中血小板反应蛋白-1的表达，并增强HT1080细胞的血小板聚集能力。TGF-βⅠ型受体抑制剂（SB431542）和针对Smad4的短发夹RNA可抑制TGF-β诱导的血小板反应蛋白-1表达。这些结果表明，TGF-β是肿瘤细胞中血小板反应蛋白-1的生理调节因子。
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