伴有间隔性脂膜炎的肾源性系统性纤维化，酷似结节性红斑。
Nephrogenic systemic fibrosis with septal panniculitis mimicking erythema nodosum.
作者信息
Naylor Elizabeth, Hu Susie, Robinson-Bostom Leslie
机构信息
Student Body, Brown Medical School, Providence, Rhode Island 02903, USA.
出版信息
J Am Acad Dermatol. 2008 Jan;58(1):149-50. doi: 10.1016/j.jaad.2007.07.018.
Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy is an idiopathic fibrosing disorder recently described in patients with renal disease. The typical histology in nephrogenic systemic fibrosis consists of haphazardly arranged dermal collagen bundles with clefting, collagenous change which extends into the subcutaneous septa, mucin deposition, fibroblast proliferation, and increased elastic fibers with minimal inflammation. We present a 65-year-old female with classic clinical features whose biopsy demonstrated unique histologic features of septal pannicilitis with lymphocytic aggregates and Miescher's radial granulomas mimicking erythema nodosum.
肾源性系统性纤维化/肾源性纤维性皮肤病是一种最近在肾病患者中被描述的特发性纤维性疾病。肾源性系统性纤维化的典型组织学表现为真皮胶原束排列紊乱，有裂隙形成，胶原变化延伸至皮下间隔，有黏液沉积、成纤维细胞增殖以及弹性纤维增多，炎症轻微。我们报告一例65岁女性患者，其具有典型临床特征，活检显示有间隔性脂膜炎的独特组织学特征，伴有淋巴细胞聚集和类似结节性红斑的米舍尔氏放射状肉芽肿。
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