Wilford Casey, Fine Jo-David, Boyd Alan S, Sanyal Soma, Abraham Jerrold L, Kantrow Sara M
Division of Dermatology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Am J Dermatopathol. 2010 Feb;32(1):71-5. doi: 10.1097/DAD.0b013e3181b0b859.
Nephrogenic systemic fibrosis (NSF) is a novel disease entity described over the past 10 years. NSF is a progressive systemic fibrosing disorder that occurs arguably exclusively in patients with impaired renal function who have been exposed to gadolinium-containing contrast agents. As no single clinical or histopathologic finding is diagnostic of NSF, a careful review of the cumulative characteristics of each case is essential in making a correct diagnosis. The spectrum of histologic variants of NSF continues to expand, including a report of NSF mimicking erythema nodosum and several case reports of NSF with giant cells and calcification. We report an additional case of NSF with the uncommon pathologic features of granulomatous and lymphocytic inflammation in the fibrous septae similar to erythema nodosum.
肾源性系统性纤维化（NSF）是过去10年中描述的一种新型疾病实体。NSF是一种进行性系统性纤维化疾病，据认为仅发生于肾功能受损且接触过含钆造影剂的患者。由于没有单一的临床或组织病理学发现可诊断NSF，因此仔细回顾每个病例的累积特征对于做出正确诊断至关重要。NSF的组织学变异谱不断扩大，包括1例类似结节性红斑的NSF报告以及几例伴有巨细胞和钙化的NSF病例报告。我们报告了另外1例NSF病例，其具有罕见的病理特征，即纤维间隔中有类似于结节性红斑的肉芽肿性和淋巴细胞性炎症。
