Quan Z F
Nanjing General Hospital, People's Liberation Army.
Zhonghua Wai Ke Za Zhi. 1991 Oct;29(10):646-8, 655.
Rabbits with MOF induced by intraabdominal sepsis were used to observe the effect of TPN with different amount of amino acid nitrogen on organ function, nitrogen balance and urine 3-MH excretion. The results showed that TPN support could improve the impaired organ function and reverse negative nitrogen balance. Low nitrogen burden was helpful to the lung, while high nitrogen appeared to be beneficial to the liver. Low nitrogen was more effective in increasing nitrogen balance and decreasing the urine 3-MH excretion. We conclude that excessive nitrogen burden results in significant thermic effect and an elevation of stress level, just as excessive glucose does.
采用腹腔感染诱导多器官功能衰竭（MOF）的兔，观察不同氨基酸氮含量的全胃肠外营养（TPN）对器官功能、氮平衡及尿3-甲基组氨酸（3-MH）排泄的影响。结果显示，TPN支持可改善受损的器官功能并扭转负氮平衡。低氮负荷对肺有益，而高氮似乎对肝脏有益。低氮在增加氮平衡和减少尿3-MH排泄方面更有效。我们得出结论，与过量葡萄糖一样，过量的氮负荷会导致显著的热效应和应激水平升高。
