一名HIV感染患者发生复方新诺明诱发的低血糖症。
Cotrimoxazole-induced hypoglycemia in an HIV-infected patient.
作者信息
Hughes C A, Chik C L, Taylor G D
机构信息
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta;
出版信息
Can J Infect Dis. 2001 Sep;12(5):314-6. doi: 10.1155/2001/848946.
Abstract
A case of cotrimoxazole-induced hypoglycemia is described in a male patient infected with HIV. Ten days after initiating high dose cotrimoxazole for suspected Pneumocystis carinii pneumonia, the patient developed neuroglycopenic symptoms and diaphoresis. Blood glucose levels were repeatedly low, with elevated insulin and C-peptide levels despite multiple intravenous bolus doses and infusions of dextrose. Hypoglycemia resolved after approximately 36 h of treatment with dextrose and discontinuation of cotrimoxazole. A review of reported cases of hypoglycemia associated with cotrimoxazole is provided, including information about onset, risk factors and possible mechanism.
摘要
本文描述了一名感染艾滋病毒的男性患者发生的一例复方新诺明诱发的低血糖症。在开始使用高剂量复方新诺明治疗疑似卡氏肺孢子虫肺炎10天后，该患者出现了神经低血糖症状和多汗。尽管多次静脉推注葡萄糖和输注葡萄糖，但血糖水平反复降低，胰岛素和C肽水平升高。在使用葡萄糖治疗约36小时并停用复方新诺明后，低血糖症得到缓解。本文还提供了对已报道的与复方新诺明相关的低血糖病例的综述，包括发病情况、危险因素和可能的机制。
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