多发性硬化症与爱泼斯坦-巴尔病毒
Multiple sclerosis and Epstein-Barr virus.
作者信息
Marrie Ruth Ann, Wolfson Christina
机构信息
Montreal Neurological Institute, McGill University.
出版信息
Can J Infect Dis. 2002 Mar;13(2):111-8. doi: 10.1155/2002/745764.
OBJECTIVE
To evaluate the epidemiological evidence for an etiological role of Epstein-Barr virus in multiple sclerosis (MS).
DATA SOURCES
MEDLINE and Cochrane Library searches of the medical literature identified 24 studies.
DATA EXTRACTION
Studies were categorized as seroepidemiological, case-control or historical cohort, and were then classified within each group according to methodological rigour using criteria derived from published guidelines for the epidemiological study of MS.
DATA SYNTHESIS
There was significant variability in the quality of evidence, and while two well-designed cohort studies found increased relative risks of MS in subjects with infectious mononucleosis, results from other studies were unconvincing.
CONCLUSIONS
The evidence was insufficient to accept or reject the hypothesis that Epstein-Barr virus has an etiological role in MS. Further study, ideally using large samples of incident cases with blinded, trained interviewers using confirmatory sources for recalled data, is needed.
目的
评估爱泼斯坦-巴尔病毒在多发性硬化症（MS）病因学中作用的流行病学证据。
数据来源
对医学文献进行MEDLINE和Cochrane图书馆检索，共识别出24项研究。
数据提取
研究被分为血清流行病学、病例对照或历史性队列研究，然后根据多发性硬化症流行病学研究已发表指南中的标准，在每组内按照方法学严谨程度进行分类。
数据综合
证据质量存在显著差异，虽然两项设计良好的队列研究发现传染性单核细胞增多症患者患MS的相对风险增加，但其他研究结果并不令人信服。
结论
证据不足以接受或拒绝爱泼斯坦-巴尔病毒在MS病因学中起作用这一假说。需要进一步开展研究，理想情况下使用大量新发病例样本，由经过培训且不知情的访谈者进行调查，并使用确证来源获取回忆数据。
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