Forward Kevin R, Lee Spencer Hs
Departments of Pathology, Medicine, and Microbiology and Immunology, Dalhousie University and the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia.
Can J Infect Dis. 2003 Mar;14(2):94-6. doi: 10.1155/2003/168673.
The epidemiology of genital herpes is changing with evidence to suggest an increasing incidence of herpes simplex virus type 1 (HSV-1) infections. The results of 6529 HSV genital cultures taken between April 1998 and December 2001 were reviewed. overall, HSV-1 was recovered more often than HSV-2; 1213 versus 1045. This trend was particularly striking in young women 30 years of age or less, in whom 70.8% of isolates were HSV-1. In men of the same age range, 45% of isolates were HSV-1. The proportion of women with HSV-1 declined from 73.7% in those younger than 31 years of age to 4.5% in those older than 60 years of age.These observations have important implications. The decline in the relative proportion of HSV-1 isolates from young adults may be the result of changing sexual practices, changing susceptibility or increased exposure to HSV-1 during vaginal intercourse. In this setting HSV-2 vaccines may be less likely to produce the desired reduction in the overall prevalence of genital herpes infections.
生殖器疱疹的流行病学正在发生变化，有证据表明单纯疱疹病毒1型（HSV-1）感染的发病率在上升。对1998年4月至2001年12月期间采集的6529份HSV生殖器培养物的结果进行了回顾。总体而言，HSV-1的检出率高于HSV-2；分别为1213例和1045例。这种趋势在30岁及以下的年轻女性中尤为明显，其中70.8%的分离株为HSV-1。在同一年龄段的男性中，45%的分离株为HSV-1。HSV-1感染女性的比例从31岁以下人群中的73.7%下降到60岁以上人群中的4.5%。这些观察结果具有重要意义。年轻成年人中HSV-1分离株相对比例的下降可能是性行为改变、易感性变化或阴道性交期间HSV-1暴露增加的结果。在这种情况下，HSV-2疫苗可能不太可能使生殖器疱疹感染的总体患病率达到预期的降低效果。
