加拿大 HIV/AIDS 患者巨细胞病毒病管理共识指南。
Canadian consensus guidelines for the management of cytomegalovirus disease in HIV/AIDS.
机构信息
Division of Infectious Diseases, McGill University Health Centre, Montréal, Quebec;
出版信息
Can J Infect Dis Med Microbiol. 2004 Nov;15(6):327-35. doi: 10.1155/2004/369390.
BACKGROUND
The management of HIV-infected patients with cytomegalovirus (CMV) disease has changed significantly with the availability of highly active antiretroviral therapy (HAART).
OBJECTIVES
These updated guidelines are intended to provide practical help to physicians managing HIV-positive patients with or at risk for CMV disease.
METHODS
The 10 members of the Canadian CMV Disease in HIV/AIDS Consensus Group were infectious disease specialists, a primary care physician and ophthalmologists with expertise in HIV and CMV infection. Financial support by Hoffmann-La Roche Canada Ltd was unrestricted, and was limited to travel expenses and honoraria. The consensus group met in June and October 2002. Key areas to be considered were identified, and group members selected, reviewed and presented relevant recent literature for their assigned section for the group's consideration. Evidence was assessed based on established criteria, which were expert opinions of the members. Draft documents were circulated to the entire group and modified until consensus was reached. The final guidelines represent the group's consensus agreement. The guidelines were approved by the Canadian Infectious Disease Society.
RESULTS AND CONCLUSIONS
The guidelines address symptom monitoring, screening for early detection and prevention, and treatment using oral, intravenous and intraocular anti-CMV therapies in conjunction with HAART.
背景
高效抗逆转录病毒治疗（HAART）的出现，使 HIV 感染者合并巨细胞病毒（CMV）病的管理发生了重大变化。
目的
本更新指南旨在为管理 HIV 阳性合并或有 CMV 病风险的患者的医生提供实用帮助。
方法
加拿大 HIV/AIDS 合并 CMV 病共识组的 10 名成员为传染病专家、一名主治医生和专攻 HIV 和 CMV 感染的眼科医生。罗氏加拿大有限公司的资助不受限制，仅用于支付差旅费和酬金。共识组于 2002 年 6 月和 10 月举行会议。确定了需要考虑的关键领域，小组成员选择、审查并提交了与其指定部分相关的近期相关文献，供小组审议。根据既定标准评估证据，这些标准是小组成员的专家意见。将草案分发给全体小组成员，并进行修改，直至达成共识。最终指南代表了小组的一致意见。加拿大传染病学会批准了该指南。
结果和结论
本指南涉及症状监测、早期检测和预防筛查，以及与 HAART 联合使用口服、静脉内和眼内抗 CMV 治疗。
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