Temizhan Ahmet
Türkiye Yüksek Ihtisas Eğitim ve Araştirma Hastanesi Kardiyoloji Kliniği, Ankara, Türkiye.
Anadolu Kardiyol Derg. 2007 Dec;7 Suppl 2:2-4.
Although aspirin is effective in the treatment of acute coronary syndrome and in the secondary prevention of cardiovascular disease among both men and women, its use in primary prevention remains controversial. The gender-specific meta-analysis demonstrates that the specific types of benefit of aspirin therapy differ between women and men in primary prevention. For primary prevention of cardiovascular disease in women, aspirin therapy significantly reduced the risk of the composite of cardiovascular events primarily by its effect on reducing the risk of stroke. In contrast, in men; aspirin therapy significantly reduced the risk of the composite of cardiovascular events predominantly by reducing the risk of myocardial infarction. The reasons for any sex-based differences in the efficacy of aspirin for primary prevention are unclear and require further exploration.
尽管阿司匹林在治疗急性冠状动脉综合征以及男性和女性心血管疾病的二级预防中均有效，但其在一级预防中的应用仍存在争议。这项针对特定性别的荟萃分析表明，阿司匹林治疗在一级预防中的具体获益类型在女性和男性之间存在差异。对于女性心血管疾病的一级预防，阿司匹林治疗主要通过降低中风风险，显著降低了心血管事件综合风险。相比之下，在男性中，阿司匹林治疗主要通过降低心肌梗死风险，显著降低了心血管事件综合风险。阿司匹林在一级预防疗效方面基于性别的差异原因尚不清楚，需要进一步探索。
