心肌肌钙蛋白I在控制心肌收缩和舒张中的独特功能。
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation.
作者信息
Solaro R John, Rosevear Paul, Kobayashi Tomoyoshi
机构信息
Department of Physiology and Biophysics (M/C901) and Center for Cardiovascular Research, 835 South Wolcott Avenue, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA.
出版信息
Biochem Biophys Res Commun. 2008 Apr 25;369(1):82-7. doi: 10.1016/j.bbrc.2007.12.114. Epub 2007 Dec 26.
Abstract
We review development of evidence and current perceptions of the multiple and significant functions of cardiac troponin I in regulation and modulation of cardiac function. Our emphasis is on the unique structure function relations of the cardiac isoform of troponin I, especially regions containing sites of phosphorylation. The data indicate that modifications of specific regions cardiac troponin I by phosphorylations either promote or reduce cardiac contractility. Thus, a homeostatic balance in these phosphorylations is an important aspect of control of cardiac function. A new concept is the idea that the homeostatic mechanisms may involve modifications of intra-molecular interactions in cardiac troponin I.
摘要
我们回顾了关于心肌肌钙蛋白I在心脏功能调节中多种重要功能的证据发展及当前认知。我们重点关注肌钙蛋白I心脏同工型独特的结构-功能关系，特别是包含磷酸化位点的区域。数据表明，磷酸化对心肌肌钙蛋白I特定区域的修饰可增强或减弱心脏收缩力。因此，这些磷酸化的稳态平衡是心脏功能控制的一个重要方面。一个新的概念是，稳态机制可能涉及心肌肌钙蛋白I分子内相互作用的修饰。
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