葡萄孢菌素A-E，来自一种寄生真菌葡萄穗霉属菌株（NRRL 38180）的去甲瑞斯托菌素类似物。

Botryolides A-E, decarestrictine analogues from a fungicolous Botryotrichum sp. (NRRL 38180).

作者信息

Sy Arlene A, Swenson Dale C, Gloer James B, Wicklow Donald T

机构信息

Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.

出版信息

J Nat Prod. 2008 Mar;71(3):415-9. doi: 10.1021/np070610d. Epub 2007 Dec 30.

DOI:10.1021/np070610d

PMID:18163662

Abstract

Four new decarestrictine analogues (botryolides A-D; 1- 4), a biosynthetically related gamma-lactone (botryolide E; 5), and the known compounds decarestrictine D ( 6) and sterigmatocystin have been isolated from cultures of a fungicolous isolate of Botryotrichum sp. (NRRL 38180). The structures of these compounds were determined by analysis of 2D NMR and ESIMS data. The relative configurations of 1- 5 were established on the basis of NMR data and/or X-ray diffraction analysis, while the absolute configuration of 1 was assigned using the modified Mosher method.

摘要

从葡萄穗霉属真菌分离物（NRRL 38180）的培养物中分离出了四种新的去甲基麦角甾毒素类似物（葡萄穗霉内酯A-D；1-4）、一种生物合成相关的γ-内酯（葡萄穗霉内酯E；5）以及已知化合物去甲基麦角甾毒素D（6）和杂色曲霉素。这些化合物的结构通过二维核磁共振（2D NMR）和电喷雾离子化质谱（ESIMS）数据进行分析确定。1-5的相对构型基于核磁共振数据和/或X射线衍射分析确定，而1的绝对构型则使用改良的莫舍尔方法确定。