Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
J Nat Prod. 2010 Mar 26;73(3):404-8. doi: 10.1021/np900613d.
Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analogue, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638). The structures and relative configurations of these compounds were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 2 was proposed on the basis of CD analysis using both empirical and computational methods. Compounds 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 3 was also active against Aspergillus flavus and Fusarium verticillioides.
从一株丛梗孢菌（MYC-1703；NRRL 37638）的真菌分离物中分离得到了海姆诺辛 A（1）、海姆诺辛 B（2）和一种新的巨孢菌素类似物，2',3'-环氧-13-羟基-4'-氧代巨孢菌素 A（3）。这些化合物的结构和相对构型是基于 2D NMR 和 MS 数据确定的，并且通过 X 射线晶体学分析证实了 1 的结构。基于使用经验和计算方法的 CD 分析，提出了 2 的绝对构型。化合物 2 和 3 对金黄色葡萄球菌和枯草芽孢杆菌具有抗菌活性。化合物 3 对黄曲霉和串珠镰刀菌也具有活性。
