Garetz Susan L
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
Otolaryngol Head Neck Surg. 2008 Jan;138(1 Suppl):S19-26. doi: 10.1016/j.otohns.2007.06.738.
To summarize published studies that evaluate whether adenotonsillectomy performed for sleep-disordered breathing in children is associated with improvements in behavior, cognitive function, and quality of life, whether those improvements show correlation with polysomnographic parameters, and suggest how future studies may provide additional clinically significant information.
A computerized search of the medical literature was performed for articles published between 1950 and March 2007 with the use of the OVID Medsearch database.
Analysis revealed 25 articles that satisfied the inclusion and exclusion criteria. All studies showed improvement in one or more of the specified outcome measures including general or disease specific quality of life, behavioral problems including hyperactivity and increased aggression or neurocognitive skills, such as memory, attention, or school performance. Limited correlation was often seen between improvements in outcome measures and polysomnographic variables.
Current studies strongly suggest adenotonsillectomy performed for sleep-disordered breathing in children is associated with improvements in quality of life, behavior, and cognitive function, but large, randomized, controlled studies are needed to provide definitive evidence of the benefits of this commonly performed surgical procedure in the general population.
总结已发表的研究，这些研究评估了因儿童睡眠呼吸障碍而进行的腺扁桃体切除术是否与行为、认知功能和生活质量的改善相关，这些改善是否与多导睡眠图参数相关，并建议未来的研究如何提供更多具有临床意义的信息。
利用OVID Medsearch数据库对1950年至2007年3月发表的医学文献进行计算机检索。
分析发现25篇文章符合纳入和排除标准。所有研究均显示一种或多种指定结局指标有所改善，包括总体或疾病特异性生活质量、行为问题（如多动和攻击性增加）或神经认知技能（如记忆、注意力或学业表现）。结局指标的改善与多导睡眠图变量之间通常存在有限的相关性。
目前的研究强烈表明，因儿童睡眠呼吸障碍而进行的腺扁桃体切除术与生活质量、行为和认知功能的改善相关，但需要大规模、随机、对照研究来提供确凿证据，证明这种常见外科手术对普通人群的益处。
