McMorris T, Collard K, Corbett J, Dicks M, Swain J P
University of Chichester, College Lane, Chichester, West Sussex PO19 6PE, UK.
Pharmacol Biochem Behav. 2008 Mar;89(1):106-15. doi: 10.1016/j.pbb.2007.11.007. Epub 2007 Nov 28.
The purpose of the study was to examine the usage of norepinephrine (NE) and dopamine (DA) in the brain when exercising while simultaneously undertaking cognitive tests. Plasma concentrations of the NE metabolite 3-methoxy 4-hydroxyphenylglycol (MHPG) and the DA metabolite homovanillic acid (HVA) showed a linear increase from rest to exercising at 40% and 80% maximum power output (W.max) while simultaneously undertaking cognitive tasks (random number generation (RNG) and response time). Delta plasma concentrations of MHPG and HVA at each exercise intensity while undertaking cognitive tasks and while exercising without cognitive tasks did not differ. Taking blood samples at 0, 1, 3, and 5 min following cessation of exercise did not affect results. Regression correlations showed that delta MHPG and HVA plasma concentrations at the 1 and 3 min sampling times were strong predictors of delta RNG, response time and movement time. Reaction time at 80% W.max significantly increased, while movement time at 80% W.max significantly decreased. It was concluded that these results provide no support for a direct effect of increased catecholamines concentrations on cognitive performance during exercise. The regression data suggest that there is some relationship between exercise, catecholamines concentrations and cognition.
该研究的目的是检测在运动同时进行认知测试时大脑中去甲肾上腺素（NE）和多巴胺（DA）的使用情况。NE代谢物3-甲氧基4-羟基苯乙二醇（MHPG）和DA代谢物高香草酸（HVA）的血浆浓度在从静息状态到以最大输出功率（W.max）的40%和80%进行运动并同时进行认知任务（随机数生成（RNG）和反应时间）时呈线性增加。在进行认知任务时以及在不进行认知任务的情况下运动时，每种运动强度下MHPG和HVA的血浆浓度变化量并无差异。在运动停止后的0、1、3和5分钟采集血样并不影响结果。回归相关性表明，在1分钟和3分钟采样时间点的MHPG和HVA血浆浓度变化量是RNG变化量、反应时间和运动时间的强预测指标。在80%W.max时反应时间显著增加，而在80%W.max时运动时间显著减少。研究得出结论，这些结果不支持运动期间儿茶酚胺浓度增加对认知表现有直接影响这一观点。回归数据表明运动、儿茶酚胺浓度和认知之间存在某种关系。
