Chen Yi-Ywan M, Feng C W, Chiu C F, Burne Robert A
Department of Microbiology and Immunology, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan.
Appl Environ Microbiol. 2008 Mar;74(5):1642-5. doi: 10.1128/AEM.01878-07. Epub 2007 Dec 28.
A CadDX system that confers resistance to Cd(2+) and Zn(2+) was identified in Streptococcus salivarius 57.I. Unlike with other CadDX systems, the expression of the cad promoter was negatively regulated by CadX, and the repression was inducible by Cd(2+) and Zn(2+), similar to what was found for CadCA systems. The lower G+C content of the S. salivarius cadDX genes suggests acquisition by horizontal gene transfer.
在唾液链球菌57.I中鉴定出一种赋予对Cd(2+)和Zn(2+)抗性的CadDX系统。与其他CadDX系统不同,cad启动子的表达受CadX负调控,且这种抑制可被Cd(2+)和Zn(2+)诱导,这与CadCA系统的情况相似。唾液链球菌cadDX基因较低的G+C含量表明其通过水平基因转移获得。