新一代测序技术改变了当今的生物学。

Next-generation sequencing transforms today's biology.

作者信息

Schuster Stephan C

机构信息

Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Building, University Park, Pennsylvania 16802, USA.

出版信息

Nat Methods. 2008 Jan;5(1):16-8. doi: 10.1038/nmeth1156. Epub 2007 Dec 19.

DOI:10.1038/nmeth1156

PMID:18165802

Abstract

A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years.

摘要

新一代非基于桑格法的测序技术兑现了其以史无前例的速度对DNA进行测序的承诺，从而取得了令人瞩目的科学成就并催生了新颖的生物学应用。然而，在成为焦点之前，新一代测序技术必须克服一个依赖桑格测序法长达30年的领域的惯性。