Lacasse Anaïs, Rey Evelyne, Ferreira Ema, Morin Caroline, Bérard Anick
Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada.
Am J Obstet Gynecol. 2008 Jan;198(1):71.e1-7. doi: 10.1016/j.ajog.2007.05.051.
The only validated nausea and vomiting of pregnancy (NVP) severity index is the Motherisk Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) index that covers symptoms in the previous 12 hours. We sought to assess the validity of a modified-PUQE index that covers the entire first trimester of pregnancy by comparing NVP severity scores between the 12-hour PUQE index and our modified-PUQE index and by measuring the extent of the association between the modified-PUQE score and quality-of-life (QOL) score during the first trimester of pregnancy.
A prospective study that included women who attended the Centre Hospitalier Universitaire Sainte-Justine or René-Laennec clinic for their prenatal visits was conducted from 2004-2006. Women were eligible if they were > or = 18 years old and < or = 16 weeks of gestation at the time of their first prenatal visit. Women who reported NVP were asked to fill out the 12-hour PUQE, the modified PUQE index, and the Short-Form Health Survey QOL index simultaneously. Intraclass correlation coefficients were calculated to determine concordance between the 2 scores. Linear regression models were built to measure the association between the modified-PUQE score and Short-Form Health Survey QOL scores.
Among participants (n = 287), the mean NVP severity score was 5.7 vs 6.7 on the 12-hour PUQE and modified PUQE, respectively (P < .05). There was substantial concordance between the indices (intraclass correlation coefficient, 0.71). Severity of NVP that was measured by the new modified index was associated with QOL.
We are confident that, on the basis of the modified-PUQE, the relationship between QOL and severity of NVP justify the use of this new index.
唯一经过验证的妊娠恶心呕吐（NVP）严重程度指数是Motherisk妊娠特异性呕吐和恶心量化（PUQE）指数，该指数涵盖过去12小时内的症状。我们试图通过比较12小时PUQE指数与我们的改良PUQE指数之间的NVP严重程度评分，并测量改良PUQE评分与妊娠早期生活质量（QOL）评分之间的关联程度，来评估涵盖妊娠整个孕早期的改良PUQE指数的有效性。
2004年至2006年进行了一项前瞻性研究，纳入了在圣朱斯汀大学医院或勒内·拉埃内克诊所进行产前检查的女性。如果女性首次产前检查时年龄≥18岁且妊娠≤16周，则符合入选条件。报告有NVP的女性被要求同时填写12小时PUQE、改良PUQE指数和简短健康调查QOL指数。计算组内相关系数以确定两个评分之间的一致性。建立线性回归模型以测量改良PUQE评分与简短健康调查QOL评分之间的关联。
在参与者（n = 287）中，12小时PUQE和改良PUQE的平均NVP严重程度评分分别为5.7和6.7（P < .05）。各指数之间存在高度一致性（组内相关系数为0.71）。新改良指数测量的NVP严重程度与QOL相关。
我们相信，基于改良PUQE，QOL与NVP严重程度之间的关系证明了使用这一新指数的合理性。
