Guglielmi S, Merz T M, Gugger M, Suter C, Nicod L P
Clinic and Policlinic for Pneumology, Bern University Hospital, Bern, Switzerland.
Eur Respir J. 2008 Jan;31(1):213-7. doi: 10.1183/09031936.00014707.
Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified. An unusual case of acute respiratory distress syndrome, secondary to such proven NSIP of cellular type with predominant CD8 lymphocytes, is described herein. The patient described in the present case study initially had a poor recovery with high dose of steroids, but this was followed by a good improvement after the prescription of tacrolimus and a low dose of prednisone. A precise diagnosis in similar circumstances may be life-saving, allowing the successful application of new immunosuppressants.
多发性肌炎和间质性肺疾病，主要是非特异性间质性肺炎（NSIP），在抗合成酶综合征中很常见，在该综合征中常可检测到抗氨酰tRNA合成酶抗体。本文描述了一例不寻常的急性呼吸窘迫综合征病例，该病例继发于经证实的细胞型NSIP，以CD8淋巴细胞为主。本病例研究中的患者最初使用大剂量类固醇治疗后恢复不佳，但在使用他克莫司和低剂量泼尼松后病情有了明显改善。在类似情况下做出准确诊断可能会挽救生命，从而能够成功应用新的免疫抑制剂。
