Sackmann Federico, Pavlovsky Miguel Arturo, Corrado Claudia, Pizzolato Marco, Alejandre Mariel, Pavlovsky Santiago
Haematologica. 2008 Jan;93(1):153-4. doi: 10.3324/haematol.11744.
A retrospective evaluation of 285 patients with monoclonal gammopathy of undetermined significance was performed to identify variables associated with progression, actuarial progression free survival (PFS) and overall survival (OS). Three variables, level of uninvolved immunoglobulins (HR 4.98, CI95% 2 -12.4, p=0.0006), monoclonal protein concentration (HR 4.04, CI95% 1.6-10.34, p=0.004), and erythrosedimentation rate (HR 3.94, CI95% 1.33-11.6, p=0.01), showed independent prognostic significance. With a median follow-up of 66 months (range 6-378), PFS and OS at 10 years were 89% and 91% respectively.
对285例意义未明的单克隆丙种球蛋白病患者进行了回顾性评估，以确定与疾病进展、精算无进展生存期（PFS）和总生存期（OS）相关的变量。三个变量，即未受累免疫球蛋白水平（风险比4.98，95%置信区间2-12.4，p=0.0006）、单克隆蛋白浓度（风险比4.04，95%置信区间1.6-10.34，p=0.004）和红细胞沉降率（风险比3.94，95%置信区间1.33-11.6，p=0.01）显示出独立的预后意义。中位随访66个月（范围6-378个月），10年时的PFS和OS分别为89%和91%。
