Rösen R, Fricke U, Stier A
Naunyn Schmiedebergs Arch Pharmacol. 1976;293(1):39-47. doi: 10.1007/BF00498869.
The binding of digitoxigenin to lecithin model membranes was investigated by application of electron spin- and nuclear magnetic resonance methods. A digitoxigenin spin-label derivative was found to bind specifically to the pseudohexagonal rigid lattice of lecithin membranes. The binding is accomplished by some of the structural features which are required for the biological activity of cardiac glycosides. Digitoxigenin has a procooperative effect on dipalmitoyl-lecithin membranes. The induction of lipid phase separation is discussed as a hypothetic molecular mechanism of action of cardiac glycosides on biological membranes.
通过电子自旋和核磁共振方法研究了洋地黄毒苷与卵磷脂模型膜的结合。发现一种洋地黄毒苷自旋标记衍生物能特异性结合到卵磷脂膜的假六边形刚性晶格上。这种结合是通过强心苷生物活性所需的一些结构特征来实现的。洋地黄毒苷对二棕榈酰卵磷脂膜有促协同作用。脂质相分离的诱导被认为是强心苷对生物膜作用的一种假设分子机制。
