强心苷元对藤壶肌纤维中钠外流的影响。
Effects of cardiac aglycones on the sodium efflux in barnacle muscle fibres.
作者信息
Bittar E E, Brown D J
出版信息
J Physiol. 1977 Jun;267(3):667-78. doi: 10.1113/jphysiol.1977.sp011832.
Abstract
- External application of 10(-4) M digitoxigenin caused an 80% fall in the Na efflux in barnacle muscle fibres. The observed inhibition was irreversible and could be produced by as little as 10(-7) M digitoxigenin. 2. Internal application of 10(-2) M digitoxigenin lowered the Na efflux by 46% but was without effect following addition of external ouabain or K removal. 3. External application of digitoxigenin (or ouabain) following internal application of the aglycone was without effect on the Na efflux. 4. The efflux of [3H]digitoxigenin was fairly rapid, whereas that of [3H]ouabain was slow. 5. Inhibition of the Na efflux by internal application of digitoxigenin is probably the result of an action of the aglycone on the external side of the membrane following its leakage from the fibre interior.
摘要
- 外用10⁻⁴ M洋地黄毒苷使藤壶肌纤维中的钠外流减少80%。观察到的抑制作用是不可逆的，低至10⁻⁷ M洋地黄毒苷就能产生这种作用。2. 内用10⁻² M洋地黄毒苷使钠外流降低46%，但在加入外用哇巴因或去除钾后无作用。3. 在糖苷配基内用后外用洋地黄毒苷（或哇巴因）对钠外流无作用。4. [³H]洋地黄毒苷的外流相当快，而[³H]哇巴因的外流则很慢。5. 内用洋地黄毒苷对钠外流的抑制可能是糖苷配基从纤维内部漏出后作用于膜外侧的结果。
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