Knibbe Carole, Fayard Jean-Michel, Beslon Guillaume
LIRIS UMR CNRS/UCBL 5205, Université Claude Bernard Lyon I, Bat. Nautibus, 69622 Villeurbanne Cedex, France.
Artif Life. 2008 Winter;14(1):149-56. doi: 10.1162/artl.2008.14.1.149.
Abstract Systems biology invites us to consider the dynamic interactions between the components of a living cell. Here, by evolving artificial organisms whose genomes encode protein networks, we show that a coupling emerges at the evolutionary time scale between the protein network and the structure of the genome. Gene order is more stable when the protein network is more densely connected, which most likely results from a long-term selection for mutational robustness. Understanding evolving organisms thus requires a systemic approach, taking into account the functional interactions between gene products, but also the global relationships between the genome and the proteome at the evolutionary time scale.
摘要 系统生物学促使我们思考活细胞各组成部分之间的动态相互作用。在此，通过培育基因组编码蛋白质网络的人工生物体，我们表明在进化时间尺度上，蛋白质网络与基因组结构之间出现了一种耦合。当蛋白质网络连接更密集时，基因顺序更稳定，这很可能是对突变稳健性进行长期选择的结果。因此，理解进化中的生物体需要一种系统方法，既要考虑基因产物之间的功能相互作用，也要考虑进化时间尺度上基因组与蛋白质组之间的全局关系。
