Viding Essi, Jones Alice P, Frick Paul J, Moffitt Terrie E, Plomin Robert
Department of Psychology, University College London, and SGDP Centre, Institute of Psychiatry, King's College London, London, UK.
Dev Sci. 2008 Jan;11(1):17-22. doi: 10.1111/j.1467-7687.2007.00648.x.
A previous finding from our group indicated that teacher-rated antisocial behaviour (AB) among 7-year-olds is particularly heritable in the presence of callous-unemotional (CU) traits. Using a sample of 1865 same-sex twin pairs, we employed DeFries-Fulker extremes analysis to investigate whether teacher-rated AB with/without CU traits also shows aetiological differences among 9-year-olds. Furthermore, we assessed whether the differences in the magnitude of heritability would be evident even when hyperactive symptoms were controlled for in the statistical analysis. AB among 9-year-olds was more heritable with than without concomitant CU. The heritability difference was even more pronounced in magnitude when hyperactive symptoms were controlled. CU traits thus appear to index one valid way of sub-typing children with early-onset AB.
我们团队之前的一项研究发现表明，在具有冷酷无情（CU）特质的情况下，7岁儿童中教师评定的反社会行为（AB）具有特别高的遗传性。我们以1865对同性双胞胎为样本，采用德弗里斯-富尔克极端分析方法，来研究教师评定的伴有或不伴有CU特质的AB在9岁儿童中是否也存在病因学差异。此外，我们评估了即使在统计分析中对多动症状进行控制，遗传度大小的差异是否依然明显。9岁儿童中，伴有CU特质的AB比不伴有CU特质的AB遗传性更强。在控制多动症状后，遗传度差异在程度上更加显著。因此，CU特质似乎是对早发性AB儿童进行亚型分类的一种有效方式。
