O'Malley F P, Bane A
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Histopathology. 2008 Jan;52(1):3-10. doi: 10.1111/j.1365-2559.2007.02888.x.
Apocrine change occurs in a spectrum of benign lesions in the female breast and is also demonstrated in a subgroup of in situ and invasive carcinomas. Recent research has focused on the molecular phenotype of both benign and malignant apocrine lesions. This review will briefly summarize the morphological characteristics and risk associations of the spectrum of apocrine proliferations, but will focus on the updated molecular studies of both in situ and invasive apocrine carcinomas.
大汗腺化生可见于女性乳腺的一系列良性病变，也见于一部分原位癌和浸润性癌。近期的研究聚焦于良性和恶性大汗腺病变的分子表型。本综述将简要总结大汗腺增生谱系的形态学特征及风险关联，但将重点关注原位和浸润性大汗腺癌的最新分子研究。
