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Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.

作者信息

Suhara Yoshitomo, Hirota Yoshihisa, Nakagawa Kimie, Kamao Maya, Tsugawa Naoko, Okano Toshio

机构信息

Department of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.

出版信息

Bioorg Med Chem. 2008 Mar 15;16(6):3108-17. doi: 10.1016/j.bmc.2007.12.025. Epub 2008 Jan 2.

DOI:10.1016/j.bmc.2007.12.025
PMID:18171617
Abstract

Novel omega-oxygenated vitamin K(2) analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs.

摘要

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Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines.
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2
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