突触前去甲肾上腺素代谢的临床方面。

Clinical aspects on presynaptic noradrenaline metabolism.

作者信息

Ludwig J, Halbrügge T, Graefe K H

机构信息

Medical School, University of Würzburg, Federal Republic of Germany.

出版信息

J Neural Transm Suppl. 1991;34:69-75. doi: 10.1007/978-3-7091-9175-0_9.

DOI:10.1007/978-3-7091-9175-0_9

PMID:1817166

Abstract

In healthy subjects, similar absolute increments in plasma noradrenaline (NA) and dihydroxyphenylglycol (DOPEG) were observed in response to upright posture or isoprenaline infusion. Blockade of neuronal uptake by desipramine abolished these plasma DOPEG responses and reduced plasma DOPEG per se. In essential hypertensives we found higher than normal plasma DOPEG levels at any given plasma NA. Evidence is provided that both the desipramine-sensitive and -resistant pool of plasma DOPEG contribute to this hypertensive-normotensive difference.

摘要

在健康受试者中，观察到血浆去甲肾上腺素（NA）和二羟苯乙二醇（DOPEG）因直立姿势或异丙肾上腺素输注而出现相似的绝对增量。地昔帕明对神经元摄取的阻断消除了这些血浆DOPEG反应，并降低了血浆DOPEG本身。在原发性高血压患者中，我们发现在任何给定的血浆NA水平下，血浆DOPEG水平均高于正常。有证据表明，血浆DOPEG中对地昔帕明敏感和耐药的部分均导致了这种高血压与正常血压的差异。