丙咪嗪和一些色胺衍生物对兔血小板中3H-5-羟色胺流出的影响。
Effects of imipramine and some tryptamine derivatives on the efflux of 3H-5-hydroxytryptamine from rabbit platelets.
作者信息
Wölfel R, Graefe K H
机构信息
Department of Pharmacology and Toxicology, University of Würzburg, Federal Republic of Germany.
出版信息
J Neural Transm Suppl. 1991;34:77-83. doi: 10.1007/978-3-7091-9175-0_10.
The efflux of 3H-5-hydroxytryptamine (3H-5-HT) from rabbit platelets (monoamine oxidase inhibited; pretreatment with reserpine) was measured in the absence and presence of various concentrations of imipramine or a number of tryptamine derivatives. The maximum efflux-accelerating effect (Emax) of 5-HT and some other tryptamines (e.g., N-methyl-5-HT, 5-methoxytryptamine) far exceeded that of imipramine, whereas the Emax for 2-methyl-5-HT did not. It is concluded that tryptamines that are more effective in releasing 3H-5-HT than imipramine have the property of being substrates of the 5-HT transporter.
在不存在和存在不同浓度的丙咪嗪或多种色胺衍生物的情况下，测定了来自兔血小板（单胺氧化酶被抑制；用利血平预处理）的3H-5-羟色胺（3H-5-HT）流出量。5-HT和其他一些色胺（如N-甲基-5-HT、5-甲氧基色胺）的最大流出加速效应（Emax）远远超过丙咪嗪，而2-甲基-5-HT的Emax则不然。得出的结论是，在释放3H-5-HT方面比丙咪嗪更有效的色胺具有作为5-HT转运体底物的特性。
Zotero 插件