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兔血小板中[3H] - 色胺的饱和摄取受到5 - 羟色胺摄取阻滞剂的抑制。

Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.

作者信息

Segonzac A, Tateishi T, Langer S Z

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):33-7. doi: 10.1007/BF00496102.

DOI:10.1007/BF00496102
PMID:6514017
Abstract

[3H]-tryptamine is taken up by rabbit platelets through an active and saturable process which is temperature sensitive, sodium-dependent and inhibited by imipramine and non-tricyclic 5-hydroxytryptamine (5-HT) uptake blockers. There is an excellent correlation between the Ki for the inhibition of [3H]-tryptamine and [3H]-5-HT uptake in rabbit platelets for a series of 5-HT uptake blockers. These results indicate that [3H]-tryptamine is actively transported through the membrane of blood platelets by the same carrier that transports 5-HT.

摘要

[3H] -色胺通过一个活跃且可饱和的过程被兔血小板摄取，该过程对温度敏感、依赖钠，并受丙咪嗪和非三环类5 -羟色胺（5 - HT）摄取阻滞剂抑制。对于一系列5 - HT摄取阻滞剂，兔血小板中抑制[3H] -色胺摄取的Ki与抑制[3H] - 5 - HT摄取的Ki之间存在极好的相关性。这些结果表明，[3H] -色胺是通过转运5 - HT的同一载体被主动转运穿过血小板膜的。

相似文献

1
Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.兔血小板中[3H] - 色胺的饱和摄取受到5 - 羟色胺摄取阻滞剂的抑制。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):33-7. doi: 10.1007/BF00496102.
2
Tryptamine, a substrate for the serotonin transporter in human platelets, modifies the dissociation kinetics of [3H]imipramine binding: possible allosteric interaction.色胺是人类血小板中血清素转运体的一种底物，它会改变[3H]丙咪嗪结合的解离动力学：可能存在变构相互作用。
J Neurochem. 1985 Feb;44(2):349-56. doi: 10.1111/j.1471-4159.1985.tb05423.x.
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Effects of imipramine and some tryptamine derivatives on the efflux of 3H-5-hydroxytryptamine from rabbit platelets.丙咪嗪和一些色胺衍生物对兔血小板中3H-5-羟色胺流出的影响。
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J Neurochem. 1985 Jul;45(1):249-56. doi: 10.1111/j.1471-4159.1985.tb05501.x.
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Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter.多种色胺及相关化合物作为血小板5-羟色胺转运体底物的证据。
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本文引用的文献

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Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin and dopamine uptake by human blood platelets.四氢-β-咔啉及相应的色胺：人血小板对血清素和多巴胺摄取的体外抑制作用
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Structural requirements for uptake into serotoninergic neurones.
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[3H]-5-甲氧基色胺不被兔血小板主动摄取。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):1-4. doi: 10.1007/BF00177742.
4
On the 5-hydroxytryptamine transport across the plasma membrane of rabbit platelets and its inhibition by imipramine.5-羟色胺在兔血小板质膜上的转运及其受丙咪嗪的抑制作用
Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):1-8. doi: 10.1007/BF00168804.
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Effects of tryptamine mediated through 2 states of the 5-HT2 receptor in calf coronary artery.色胺通过5-羟色胺2受体的两种状态介导对小牛冠状动脉的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):484-92. doi: 10.1007/BF00182720.
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Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter.多种色胺及相关化合物作为血小板5-羟色胺转运体底物的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1992 Feb;345(2):129-36. doi: 10.1007/BF00165727.
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[3H]Tryptamine: high affinity binding sites in rat brain.
Eur J Pharmacol. 1982 Mar 26;78(4):475-8. doi: 10.1016/0014-2999(82)90492-7.
5
Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers.血清素和非三环类血清素摄取阻滞剂对[3H]丙咪嗪结合的复杂抑制作用。
J Neurochem. 1983 Mar;40(3):622-8. doi: 10.1111/j.1471-4159.1983.tb08026.x.
6
3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers.未治疗的抑郁症患者和对照志愿者血小板中3H-丙咪嗪结合及5-羟色胺摄取情况
Psychopharmacology (Berl). 1982;77(4):332-5. doi: 10.1007/BF00432765.
7
Substituted tetrahydro-beta-carbolines are possible candidates as endogenous ligand of the [3H]imipramine recognition site.
Eur J Pharmacol. 1984 Feb 10;98(1):153-4. doi: 10.1016/0014-2999(84)90126-2.
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Binding of [3H]imipramine and [3H]desipramine as biochemical tools for studies in depression.
Neuropharmacology. 1983 Mar;22(3 Spec No):407-13. doi: 10.1016/0028-3908(83)90190-9.
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Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?
Prog Neurobiol. 1982;19(1-2):117-39. doi: 10.1016/0301-0082(82)90023-5.
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Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.5-羟色胺及几种类似物对人体血小板的相对活性及摄取情况
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