Nieves Jeri W, Li Tracy, Zion Marsha, Gussekloo Jacobijn, Pahor Marco, Bernabei Roberto, Simon Henry, Williams G Rhys, Lapuerta Pablo
Helen Hayes Hospital, West Haverstraw, NY 10993, USA.
Aging Clin Exp Res. 2007 Dec;19(6):484-91. doi: 10.1007/BF03324735.
The aim of this study was to assess annual changes in the continuous summary physical performance score (CSPPS) and the quartile summary physical performance (QSPPS) score, evaluate how these changes relate to self-reported changes in physical function and to examine clinically meaningful changes in CSPPS and QSPPS.
This was a longitudinal study of an elderly cohort of men and women (age>65) reporting at least two domains of disability from 5 centers in the US and Europe. Subjects completed assessments of mobility, ability to perform activities of daily living (ADLs), and the physical component of the SF-36 at both baseline and at 1- year, as well as a self-report of change in function over the year. Timed physical performance tests including walking speed, repeated chair stands and balance were used to calculate QSPPS and CSPPS at baseline and one year.
Regardless of the tool used to evaluate clinical significance (ADL, SF- 36 PF, mobility disability, self-rating of physical performance) or a determination of the small meaningful change estimates based on effect size, it appears that a change of approximately 3 points in the CSPPS or 0.6 points in the QSPPS is clinically meaningful.
In this cohort with moderate to severe disability, an annual change of approximately 3 points in CSPPS and 0.6 points in QSPPS are clinically meaningful and these changes are evident at one year.
本研究旨在评估连续综合体能表现评分（CSPPS）和四分位数综合体能表现（QSPPS）评分的年度变化，评估这些变化与自我报告的身体功能变化之间的关系，并检查CSPPS和QSPPS具有临床意义的变化。
这是一项针对美国和欧洲5个中心的老年男性和女性队列（年龄>65岁）的纵向研究，这些受试者报告至少有两个残疾领域。受试者在基线和1年时完成了对活动能力、日常生活活动（ADL）能力以及SF-36身体成分的评估，以及对一年来功能变化的自我报告。在基线和一年时，使用包括步行速度、重复起坐和平衡能力在内的定时体能测试来计算QSPPS和CSPPS。
无论使用何种工具评估临床意义（ADL、SF-36身体功能、活动能力残疾、体能表现自我评分），还是根据效应量确定有意义的小变化估计值，似乎CSPPS变化约3分或QSPPS变化约0.6分具有临床意义。
在这个中度至重度残疾的队列中，CSPPS每年变化约3分和QSPPS每年变化约0.6分具有临床意义，且这些变化在一年时就很明显。
