Obara T, Ohkubo T, Asayama K, Metoki H, Inoue R, Kikuya M, Kato T, Tanaka K, Hara A, Hashimoto J, Totsune K, Imai Y
Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan.
J Hum Hypertens. 2008 Mar;22(3):197-204. doi: 10.1038/sj.jhh.1002320. Epub 2008 Jan 3.
The usefulness of self-measurements of blood pressure (BP) at home (home BP measurements) in hypertensive patients has been reported by many studies. Several national guidelines recommend the use of home BP measurements to achieve better hypertension control. The objective of this study was to clarify the association between home BP measurements and hypertension treatment among 2363 essential hypertensive patients taking antihypertensive drugs. Compared to the 543 (23.0%) patients who had not taken home BP measurements, the 1820 (77.0%) patients who had taken home BP measurements were significantly older, included a higher proportion of males, included a higher proportion with a family history of hypertension, took a greater number of antihypertensive drugs and alpha blockers and took antihypertensive drugs more often in the evening. Home BP measurements were associated with significantly better control of home and office BP levels. Compared to patients who had not taken home BP measurements, the adjusted odds ratios for good control of morning home BPs, evening home BPs and office BPs in patients who had taken home BP measurements were 1.46 (95% confidential interval (CI) 1.33-1.57), 1.35 (95% CI 1.21-1.47) and 1.23 (95% CI 1.06-1.37), respectively. Home BP measurements were associated with good hypertensive management. Our findings suggest that it is important that physicians recommend home BP measurements to their patients.
许多研究报告了高血压患者在家自行测量血压（家庭血压测量）的有用性。多项国家指南推荐使用家庭血压测量来更好地控制高血压。本研究的目的是阐明2363名正在服用抗高血压药物的原发性高血压患者中家庭血压测量与高血压治疗之间的关联。与543名（23.0%）未进行家庭血压测量的患者相比，1820名（77.0%）进行了家庭血压测量的患者年龄显著更大，男性比例更高，有高血压家族史的比例更高，服用的抗高血压药物和α受体阻滞剂数量更多，且更常在晚上服用抗高血压药物。家庭血压测量与家庭和诊室血压水平的显著更好控制相关。与未进行家庭血压测量的患者相比，进行了家庭血压测量的患者中，早晨家庭血压、晚上家庭血压和诊室血压良好控制的校正比值比分别为1.46（95%置信区间（CI）1.33 - 1.57）、1.35（95%CI 1.21 - 1.47）和1.23（95%CI 1.06 - 1.37）。家庭血压测量与良好的高血压管理相关。我们的研究结果表明，医生向患者推荐家庭血压测量很重要。
