Morsczeck Christian, Schmalz Gottfried, Reichert Torsten Eugen, Völlner Florian, Galler Kerstin, Driemel Oliver
Institute of Human Genetics, University of Regensburg, Regensburg, Germany.
Clin Oral Investig. 2008 Jun;12(2):113-8. doi: 10.1007/s00784-007-0170-8. Epub 2008 Jan 3.
Complex human tissues harbour stem cells and/or precursor cells, which are responsible for tissue development or repair. Recently, dental tissues such as periodontal ligament (PDL), dental papilla or dental follicle have been identified as easily accessible sources of undifferentiated cells. The dental stem cell biology might provide meaningful insights into the development of dental tissues and cellular differentiation processes. Dental stem cells could also be feasible tools for dental tissue engineering. Constructing complex structures like a periodontium, which provides the functional connection between a tooth or an implant and the surrounding jaw, could effectively improve modern dentistry. Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This review gives a short overview of stem cells of dental origin.
复杂的人体组织含有干细胞和/或前体细胞，它们负责组织的发育或修复。最近，牙周韧带（PDL）、牙乳头或牙囊等牙组织已被确定为未分化细胞的容易获取的来源。牙干细胞生物学可能为牙组织的发育和细胞分化过程提供有意义的见解。牙干细胞也可能是牙组织工程的可行工具。构建像牙周膜这样的复杂结构，它提供牙齿或植入物与周围颌骨之间的功能连接，可以有效地改善现代牙科。牙前体细胞对于治疗牙周炎、龋齿等疾病或改善牙髓愈合以及颅面骨和牙齿再生的新方法具有吸引力。这些细胞很容易获取，并且与骨髓来源的间充质干细胞相比，与牙组织的关系更密切。本综述简要概述了牙源性干细胞。
