Ramli Hidayah, Yusop Norhayati, Ramli Rosmaliza, Berahim Zurairah, Peiris Roshan, Ghani Nurhafizah
Basic and Medical Sciences Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia.
Periodontic Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kelantan 16150, Kota Bharu, Malaysia.
Saudi Dent J. 2023 Jul;35(5):387-394. doi: 10.1016/j.sdentj.2023.05.004. Epub 2023 May 12.
Although there have been many studies on stem cells, few have investigated how neurotransmitters and stem cell proliferation interact to regenerate dental pulp. Dental pulp regeneration is an innovative procedure for reviving dental pulp, if feasible for the entire tooth. Upon tooth injury, activated platelets release serotonin and dopamine in bulk to mobilize dental pulp stem cells to mediate natural dental repair. This has induced research on the role of neurotransmitters in increasing the proliferation rate of stem cells. This review also covers prospective future treatments for dental pulp regeneration.
A literature search was performed via PubMed and ScienceDirect from 2001 to 2022, using the keywords "neurotransmitter," "stem cell," "tooth regeneration," "tooth repair," "regenerative dentistry," and "dental pulp." Different inclusion/exclusion criteria were used, and the search was restricted to English articles.
Nine publications reporting neurotransmitter interactions with stem cells for tooth and pulp regeneration were selected.
Neurotransmitters were found to interact with dental stem cells. Evidence pointing to neurotransmitters as a factor in the increased proliferation of stem cells was found. This review thus gives hope for tooth pulp regeneration and repair.
尽管已有许多关于干细胞的研究，但很少有人研究神经递质与干细胞增殖如何相互作用以再生牙髓。牙髓再生是一种恢复牙髓活力的创新方法，如果对整颗牙齿可行的话。牙齿受伤时，活化的血小板会大量释放血清素和多巴胺，以动员牙髓干细胞来介导天然牙齿修复。这引发了对神经递质在提高干细胞增殖率方面作用的研究。本综述还涵盖了牙髓再生未来可能的治疗方法。
通过PubMed和ScienceDirect数据库对2001年至2022年的文献进行检索，使用关键词“神经递质”“干细胞”“牙齿再生”“牙齿修复”“再生牙科”和“牙髓”。采用不同的纳入/排除标准，检索仅限于英文文章。
筛选出9篇关于神经递质与干细胞相互作用以实现牙齿和牙髓再生的文献。
发现神经递质与牙干细胞相互作用。有证据表明神经递质是干细胞增殖增加的一个因素。因此，本综述为牙髓再生和修复带来了希望。
