Gentile Francesco, Ferrari Mauro, Decuzzi Paolo
Center of Bio-/Nanotechnology and -/Engineering for Medicine-BioNEM, University of Magna Graecia at Catanzaro, Viale Europa-Loc. Germaneto, 88100 Catanzaro, Italy.
Ann Biomed Eng. 2008 Feb;36(2):254-61. doi: 10.1007/s10439-007-9423-6. Epub 2008 Jan 3.
The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (Deff) depending non-linearly on the rheological parameter xi(c), the ratio between the plug and the vessel radii; and on the permeability parameters pi and omega, related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of xi(c) or pi has the effect of reducing Deff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.
以被描述为卡森流体的血液为基础，分析了纳米颗粒在血管中的纵向传输。从著名的泰勒和阿里斯理论出发，已经推导出了有效纵向扩散系数（Deff）的显式表达式，该表达式非线性地依赖于流变参数xi(c)（即栓塞半径与血管半径之比）以及渗透率参数pi和omega，其中pi和omega分别与血管壁的水力传导率和压降有关。xi(c)或pi的增加会降低Deff，因此血液的流变学特性和血管的渗透率都可能构成纳米颗粒血管内递送的生理屏障。
