Petrow J M
Nervenklinik, Universität Rostock.
Z Gesamte Inn Med. 1990 Sep 15;45(18):535-40.
By means of network analysis and the use of a model which stimulates continuous blood supply to the tissue the basis of Starling's hypothesis of microcirculation is challenged. Contrary to the Starling's conception, we found that the microcirculation in the tissue is a stable process, whereby the interstitial hydraulic pressure (IHP) depends on the intracapillary blood pressure, on the permeability of the capillary wall, on the colloid-osmotic pressure and on the static pressure in the vessels and form a characteristic gradient along the capillary wall. The main effect of the colloid-osmotic pressure cannot be regarded as counteracting to the blood pressure, but instead consists in reduction of the IHP. Based on a theoretical conception about elastic interactions in the tissue a new method for measurement of the capillary filtration coefficients (CFC) is developed. Applying the method on the rabbit skeletal muscle the CFC is found to be 0.130 ml/min.mm Hg.100 g. This value is substantially higher than the values obtained from similar experiments reported in the literature (0.008 ml/min.mm Hg.100 g). The lymphatic fluid is not a result of a disbalance between filtration and resorption across the capillary wall, but it is a consequence of the protein recirculation in the following manner: blood vessels--interstitial space--lymphatic vessels--blood vessels. This recirculation is essential for the vital function of the tissue cells.
通过网络分析以及使用一种模拟向组织持续供血的模型，对斯塔林微循环假说的基础提出了挑战。与斯塔林的观点相反，我们发现组织中的微循环是一个稳定的过程，在此过程中，组织液压（IHP）取决于毛细血管内血压、毛细血管壁的通透性、胶体渗透压以及血管中的静压，并沿毛细血管壁形成一个特征性梯度。胶体渗透压的主要作用不能被视为对血压的抵消，而是在于降低IHP。基于对组织中弹性相互作用的理论概念，开发了一种测量毛细血管滤过系数（CFC）的新方法。将该方法应用于兔骨骼肌，发现CFC为0.130 ml/min·mmHg·100 g。该值显著高于文献报道的类似实验所得值（0.008 ml/min·mmHg·100 g）。淋巴液不是毛细血管壁滤过与重吸收失衡的结果，而是蛋白质以如下方式再循环的结果：血管——组织间隙——淋巴管——血管。这种再循环对于组织细胞的 vital 功能至关重要。 （注：原文中“vital”在句中含义不太明确，推测可能是“重要的”之类意思，这里按字面翻译为“vital”）
