Lowe Thomas, Ferrell Betty, Leong Lucille
City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, USA.
Curr Treat Options Oncol. 2007 Dec;8(6):402-16. doi: 10.1007/s11864-007-0049-6.
The importance of quality-of-life (QOL) measurements in cancer management is being increasingly appreciated. This is especially important in patients with advanced cancers. Over 80% of women with epithelial ovarian cancer (EOC) will present with disease outside the ovary as there are no accurate screening tests, and symptoms usually do not develop until EOC has spread. Standard treatment includes debulking surgery followed by chemotherapy to which most women will have a complete response but only a minority of women with advanced disease will be cured. Fortunately, advances in surgical and chemotherapeutic management have improved overall survival with 45% of women of all stages living 5 years or longer. EOC may in many cases be considered a "chronic cancer," which highlights the importance of QOL in management decisions. QOL may be affected by the disease itself as well as by surgical and chemotherapeutic treatments. Future studies of the care and treatment of EOC patients should include well-designed QOL evaluations.
生活质量（QOL）测量在癌症管理中的重要性正日益受到重视。这在晚期癌症患者中尤为重要。由于没有准确的筛查测试，超过80%的上皮性卵巢癌（EOC）女性患者就诊时疾病已扩散至卵巢外，且症状通常直到EOC扩散才会出现。标准治疗包括减瘤手术，随后进行化疗，大多数女性对此会有完全反应，但只有少数晚期疾病女性会被治愈。幸运的是，手术和化疗管理方面的进展提高了总体生存率，所有阶段的女性中有45%能存活5年或更长时间。在许多情况下，EOC可被视为一种“慢性癌症”，这凸显了QOL在管理决策中的重要性。QOL可能受到疾病本身以及手术和化疗治疗的影响。未来对EOC患者护理和治疗的研究应包括精心设计的QOL评估。
