一项为期12周的关于多奈哌齐对老年双相情感障碍认知功能和日常生活工具性活动影响的开放标签试验研究。
A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder.
作者信息
Gildengers Ariel G, Butters Meryl A, Chisholm Denise, Reynolds Charles F, Mulsant Benoit H
机构信息
The Advanced Center for Intervention and Services Research, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Int J Geriatr Psychiatry. 2008 Jul;23(7):693-8. doi: 10.1002/gps.1962.
OBJECTIVE
To determine whether donepezil is effective in enhancing cognitive functioning and instrumental activities of daily living (IADLs) in older adults with bipolar disorder.
METHODS
Twelve elderly patients with bipolar I or II disorder, with evidence of mild cognitive decrements, were administered donepezil 5-10 mg daily for 3 months. Participants had cognitive and functional evaluation pre-, on-, and 3-months post donepezil administration.
RESULTS
Three subjects dropped out of the study. In the remaining nine subjects, no significant effects were observed in cognitive and functional measures. Seven of the nine participants asked to resume the medication after completion of the study because of the perceived beneficial effects.
CONCLUSIONS
In this small pilot study of older adults with bipolar disorder, acute treatment with donepezil was not associated with improvements in cognitive and IADL functioning. Given limitations of the study design, placebo effects could not be ruled out in the subjects who asked to resume donepezil.
目的
确定多奈哌齐对双相情感障碍老年患者的认知功能及日常生活工具性活动（IADL）是否有效。
方法
选取12例患有双相I型或II型障碍且有轻度认知功能减退证据的老年患者，每日给予5 - 10毫克多奈哌齐，持续3个月。参与者在多奈哌齐给药前、给药期间及给药后3个月进行认知和功能评估。
结果
3名受试者退出研究。在其余9名受试者中，未观察到认知和功能指标有显著影响。9名参与者中有7名在研究结束后因感觉有有益效果而要求恢复用药。
结论
在这项针对双相情感障碍老年患者的小型初步研究中，多奈哌齐的急性治疗与认知功能及IADL功能的改善无关。鉴于研究设计的局限性，在要求恢复使用多奈哌齐的受试者中不能排除安慰剂效应。
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