Cabaravdić Mirsad
Zavod za Medicinu rada Kantona Sarajevo.
Med Arh. 2006;60(6 Suppl 2):97-100.
There is considerable concern about the increasing incidence of endocrine-related cancer and deteriorating reproductive health in humans. A large number of natural and man-made chemicals have the ability to mimic the action of the endogenous steroid hormone 17beta-estradiol by binding to and activating the estrogen receptor. Although there is no consensus regarding the role of xenoestrogens in these effects and no conclusive studies demonstrating that xenoestrogens initiate or contribute to the development of these effects. The molecular structure of exogenous natural and synthetic estrogens may be very similar to, or strikingly different from the natural hormone. Despite their structural diversity, all of the exogenous estrogens, when ingested either as natural compounds (phytoestrogens, mycoestrogens) or contaminants (xenoestrogens), have the capacitiy to bind to the ER at a given concentration in target cells of the body and can initiate (agonist) or inhibit (antagonist) estrogen-like actions. Assessment of the impact of xenoestrogenic compounds will require additional research on identification and quantitation of these compounds in serum, their interactions with plasma and cellular proteins, and their uptake in target tissues. Aim of this paper is to show the possible estrogenic effects of polcycylic aromatic hydrocarbons (PAHs), organochlorines-persistent organic pollutants (POPs) and phytoestrogens.
人们对人类内分泌相关癌症发病率的上升以及生殖健康的恶化深感担忧。大量天然和人造化学物质能够通过与雌激素受体结合并激活它，来模拟内源性甾体激素17β-雌二醇的作用。尽管对于外源性雌激素在这些影响中所起的作用尚无共识，也没有确凿的研究表明外源性雌激素引发或促成了这些影响。外源性天然和合成雌激素的分子结构可能与天然激素非常相似，也可能截然不同。尽管它们结构多样，但所有外源性雌激素，无论是作为天然化合物（植物雌激素、霉菌雌激素）还是污染物（外源性雌激素）摄入，在体内靶细胞中给定浓度下都有能力与雌激素受体结合，并能引发（激动剂）或抑制（拮抗剂）雌激素样作用。评估外源性雌激素化合物的影响将需要对这些化合物在血清中的鉴定和定量、它们与血浆和细胞蛋白的相互作用以及它们在靶组织中的摄取进行更多研究。本文的目的是展示多环芳烃（PAHs）、有机氯持久性有机污染物（POPs）和植物雌激素可能的雌激素效应。
