Teisseyre Mikołaj, Pawłowska Joanna, Kryśkiewicz Edyta, Karczmarewicz Elzbieta, Czubkowski Piotr, Dadalski Maciej, Jankowska Irena, Teisseyre Joanna, Ismail Hor, Lorenc Roman
Department of Gastroenterology, Hepatology and Immunology, Children's Memorial Health Institute, Warsaw, Poland.
Ann Transplant. 2007;12(2):19-25.
Aim of the study was to analyze the effect of living related liver transplantation on selected parameters of bone formation and resorption in children with liver cirrhosis caused by biliary atresia.
MATERIAL/METHODS: 20 children (13F/7M) with biliary atresia aged from 6 month to 2.4 years were enrolled into the study 4-9 days before liver transplantation. Osteocalcin, procollagen 1 aminoterminal propeptide, collagen type 1 crosslinked C-telopeptide, parathyroid hormone and metabolites of vitamin D: 25(OH)D3, 1,25(OH)2D3 were measured before, 3, 6 and 12 months after liver transplantation.
Three months after living related liver transplantation statistically significant increase of osteocalcin, collagen type 1 crosslinked C-telopeptide, parathyroid hormone and 1,25(OH)2D3 levels were found. We didn't observe further increase of these parameters during the next 9 months after liver transplantation. There was no difference in 25(OH)D3 levels in patients before and after liver transplantation.
In children after successful living related liver transplantation we observed improvement of selected parameters of bone formation and resorption which indicate stimulation of growing processes and mechanisms of bone geometry modelling.
本研究旨在分析亲属活体肝移植对胆道闭锁所致肝硬化患儿骨形成和骨吸收相关指标的影响。
材料/方法：20例年龄在6个月至2.4岁之间的胆道闭锁患儿在肝移植术前4 - 9天纳入研究。在肝移植术前、术后3个月、6个月和12个月检测骨钙素、I型前胶原氨基端前肽、I型胶原交联C末端肽、甲状旁腺激素以及维生素D的代谢产物：25(OH)D3、1,25(OH)2D3。
亲属活体肝移植术后3个月，骨钙素、I型胶原交联C末端肽、甲状旁腺激素和1,25(OH)2D3水平出现统计学显著升高。在肝移植后的接下来9个月中，我们未观察到这些指标的进一步升高。肝移植前后患者的25(OH)D3水平无差异。
在成功进行亲属活体肝移植的患儿中，我们观察到骨形成和骨吸收相关指标有所改善，这表明生长过程以及骨几何形态塑造机制受到了刺激。
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