Hall Scott S, Lightbody Amy A, Reiss Allan L
Department of Psychiatry, Stanford University, CA 94305-5795, USA.
Am J Ment Retard. 2008 Jan;113(1):44-53. doi: 10.1352/0895-8017(2008)113[44:CSAABI]2.0.CO;2.
Compulsive, self-injurious, and autistic behaviors were examined in 31 boys and 29 girls with fragile X syndrome aged 5 to 20 years. Self-injurious behavior occurred in 58% of boys and 17% of girls, whereas compulsive behavior occurred in 72% of boys and 55% of girls and did not appear to be associated with self-injurious behavior. Fifty percent of boys and 20% of girls met diagnostic criteria for autism on the ADOS-G. Girls who showed compulsive behavior had lower levels of FMRP than girls who did not show compulsive behavior, and boys with autistic symptoms had lowered levels of cortisol. Taken together, these data suggest that autistic and compulsive behaviors are highly prevalent in fragile X syndrome and that lowered levels of FMRP and cortisol may be biological markers for these behaviors.
对31名年龄在5至20岁的患有脆性X综合征的男孩和29名女孩进行了强迫行为、自我伤害行为和自闭症行为的检查。58%的男孩和17%的女孩出现自我伤害行为，而72%的男孩和55%的女孩出现强迫行为，且强迫行为似乎与自我伤害行为无关。50%的男孩和20%的女孩在自闭症诊断观察量表修订版（ADOS-G）上符合自闭症的诊断标准。表现出强迫行为的女孩的脆性X智力低下蛋白（FMRP）水平低于未表现出强迫行为的女孩，有自闭症症状的男孩的皮质醇水平较低。综合来看，这些数据表明自闭症和强迫行为在脆性X综合征中非常普遍，FMRP和皮质醇水平降低可能是这些行为的生物学标志物。
