Wilson Michael L, Winn Washington
Department of Pathology and Laboratory Services, Denver Health Medical Center, 777 Bannock St., Denver, CO 80204-4507, USA.
Clin Infect Dis. 2008 Feb 1;46(3):453-7. doi: 10.1086/525535.
The diagnosis of infections of bones, joints, skin, and soft-tissues requires the combined use of a number of laboratory and pathology tests. The diagnosis of most infections requires microbiological cultures, both for isolation and for identification of causative organisms, as well as for antimicrobial susceptibility testing. Chemical analysis of joint fluids and histopathologic examination of infected tissues are often necessary to distinguish infections from other causes of inflammation, as well as to provide information as to the type of infection before the results of cultures are available. At this time, the use of molecular amplification tests is of limited value in the diagnosis of these infections, their value primarily being as adjunct tests for the diagnosis of rare or unusual infections.
骨骼、关节、皮肤和软组织感染的诊断需要综合运用多种实验室和病理学检查。大多数感染的诊断需要进行微生物培养，以分离和鉴定病原体，同时进行抗菌药物敏感性测试。关节液的化学分析和感染组织的组织病理学检查通常对于区分感染与其他炎症原因是必要的，并且在培养结果出来之前提供有关感染类型的信息。目前，分子扩增检测在这些感染的诊断中价值有限，其主要价值在于作为诊断罕见或不寻常感染的辅助检测手段。
