Khandpur Sujay, Bansal Arika, Ramam M, Sharma Vinod K, Das Anup Kumar, Singh Manoj K, Prasad H Krishna
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Int J Dermatol. 2007 Dec;46(12):1298-301. doi: 10.1111/j.1365-4632.2007.03374.x.
Cutaneous tuberculosis shows wide clinical variation depending upon the virulence of the organism and host immunity. Tuberculids are difficult to diagnose since the organism often cannot be identified or isolated by microscopy, culture or polymerase chain reaction. The diagnosis rests primarily on the identification of a tuberculous focus elsewhere in the body and response to antitubercular therapy. We present the clinicopathological features of an unusual tuberculid in a 30-year-old man, remarkably mimicking Kyrle's disease. He presented with multiple, symmetrically distributed follicular and perifollicular verrucous papules, nodules and plaques on the face, earlobes and extremities since 4 years. Histopathology revealed parakeratotic follicular plug invaginating into the dermis with multiple caseating epithelioid cell granulomas. PCR for M. tuberculosis was negative. The identification of associated axillary tubercular lymphadenitis, strongly positive Mantoux reaction, tuberculoid granulomas on histopathology and complete resolution of the lesions with antitubercular therapy helped in making the diagnosis. We propose the term "verrucous tuberculid" for this entity.
皮肤结核根据病原体的毒力和宿主免疫力表现出广泛的临床差异。结核疹难以诊断,因为通过显微镜检查、培养或聚合酶链反应通常无法识别或分离出病原体。诊断主要基于身体其他部位结核病灶的识别以及对抗结核治疗的反应。我们报告了一名30岁男性不寻常结核疹的临床病理特征,其显著模仿了 Kyrle 病。他4年来面部、耳垂和四肢出现多个对称分布的毛囊性和毛囊周围疣状丘疹、结节和斑块。组织病理学显示角化不全的毛囊栓侵入真皮,伴有多个干酪样上皮样细胞肉芽肿。结核分枝杆菌的聚合酶链反应为阴性。相关腋窝结核性淋巴结炎的识别、结核菌素试验强阳性、组织病理学上的结核样肉芽肿以及抗结核治疗后病变完全消退有助于做出诊断。我们建议将这个实体称为“疣状结核疹”。