Ogden Lazarre, Love Georgette, Basta Susan
Department of Anesthesiology, University of Utah Health Science Center, Salt Lake City, Utah, USA.
Int J Dermatol. 2008 Jan;47(1):87-90. doi: 10.1111/j.1365-4632.2007.03331.x.
The lidocaine 7%-tetracaine 7% (LT) peel has been demonstrated to be useful for a variety of dermatologic applications, including cosmetic, laser, and vascular access procedures. Aim To measure and evaluate the detectable plasma levels and safety of lidocaine and tetracaine in adult volunteers after a single application of an LT peel, a novel method of topical anesthesia that does not require occlusion.
A randomized, factorial design study was used to evaluate the pharmacokinetic profile of lidocaine and tetracaine after a single application of the LT peel in adult volunteers (n = 36; mean age, 26.6 years). The LT peel was applied to the anterior surface of the left or right thigh of volunteers for 30, 60, or 90 min over a 50-, 100-, or 200-cm(2) area. Venous blood samples were collected at 0, 30, 60, 90, 120, 150, 180, 210, 300, and 420 min after the initial application of the LT peel.
At all time points, plasma concentrations of lidocaine and tetracaine were below the limits of quantification for the assay: 100 ng/mL and 5 ng/mL, respectively. Because of the lack of concentrations above the limit of quantification, it was not possible to determine the pharmacokinetic parameters, other than the maximum concentrations of < 100 ng/mL for lidocaine and < 5 ng/mL for tetracaine. A single application of the LT peel was well tolerated, and no study subject reported an adverse event.
A single application of LT peel to up to 200 cm(2) of anterior thigh in adults with a duration of up to 90 min produces systemic levels of lidocaine and tetracaine that are of no clinical significance at all time points measured up to 420 min after the initial application.
7%利多卡因-7%丁卡因（LT）剥脱术已被证明可用于多种皮肤科应用，包括美容、激光和血管通路手术。目的：测量并评估单次应用LT剥脱术（一种无需封闭的新型局部麻醉方法）后成年志愿者体内可检测到的利多卡因和丁卡因血浆水平及安全性。
采用随机析因设计研究，评估成年志愿者（n = 36；平均年龄26.6岁）单次应用LT剥脱术后利多卡因和丁卡因的药代动力学特征。将LT剥脱术应用于志愿者左大腿或右大腿前表面，面积为50、100或200平方厘米，持续30、60或90分钟。在首次应用LT剥脱术后0、30、60、90、120、150、180、210、300和420分钟采集静脉血样。
在所有时间点，利多卡因和丁卡因的血浆浓度均低于检测的定量限：分别为100纳克/毫升和5纳克/毫升。由于缺乏高于定量限的浓度，除了利多卡因最大浓度<100纳克/毫升和丁卡因最大浓度<5纳克/毫升外，无法确定药代动力学参数。单次应用LT剥脱术耐受性良好，没有研究对象报告不良事件。
在成年人中，单次将LT剥脱术应用于大腿前部多达200平方厘米的面积，持续时间长达90分钟，在首次应用后长达420分钟测量的所有时间点，利多卡因和丁卡因的全身水平均无临床意义。
