Hauer Julie M
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Dev Med Child Neurol. 2008 Jan;50(1):68-70. doi: 10.1111/j.1469-8749.2007.02002.x.
Children with severe neurodevelopmental impairment are at risk for recurrent hypothermia, defined as a temperature of less than 35 degrees C, as a result of hypothalamic dysfunction. Acute pancreatitis following hypothermia from environmental exposure or induced as medical therapy has been reported in adults. In this case series of 10 children (six males, four females) with severe neurodevelopmental impairment and associated hypothermia, five had an episode of acute pancreatitis. These five patients had documented hypothermia, an elevated lipase of greater than 1000U/L, and presenting symptoms of irritability or lethargy along with gastrointestinal symptoms such as feeding intolerance. Four of these five children had no other explanation for pancreatitis; the fifth had multiple gallstones. This case series identifies the risk of acute pancreatitis in children with central hypothermia. Monitoring for resolution upon establishment of euthermia can minimize unnecessary testing and cost.
患有严重神经发育障碍的儿童因下丘脑功能障碍有反复体温过低（定义为体温低于35摄氏度）的风险。成人中已有因环境暴露导致体温过低或作为医学治疗诱发而发生急性胰腺炎的报道。在这个包含10名患有严重神经发育障碍及相关体温过低的儿童（6名男性，4名女性）的病例系列中，有5名出现了急性胰腺炎发作。这5名患者有体温过低的记录，脂肪酶升高超过1000U/L，并有烦躁或嗜睡等症状以及如喂养不耐受等胃肠道症状。这5名儿童中有4名没有胰腺炎的其他病因；第5名有多个胆结石。这个病例系列确定了中枢性体温过低儿童发生急性胰腺炎的风险。在体温恢复正常后监测病情缓解情况可将不必要的检查和费用降至最低。
