Chen H, Teixeira F B, Ritter A L, Levin L, Trope M
Private Practice, Durham, NC, USA.
Dent Traumatol. 2008 Feb;24(1):74-8. doi: 10.1111/j.1600-9657.2006.00483.x.
The prognosis of replanted teeth depends on several factors, the most important being the length of extra-oral dry time. Studies show that after 60 min dry time, root resorption is predicted. Immediate intracanal placement of Ledermix, a paste containing triamcinolone (corticosteroid) and demeclocycline (tetracycline) has been shown to inhibit root resorption after extended dry time. However, discoloration is possible from the tetracycline in Ledermix. To evaluate the individual influence of corticosteroid and tetracycline on external root resorption after extended extra-oral dry time. Sixty-nine premolar roots of four beagle dogs were extracted and instrumented with NiTi files. Group 1 (negative control) was immediately replanted after root filling with GP and sealer; Group 2 (positive control) was root filled with GP and sealer and replanted after 60 min dry time; In groups 3-5, the canals were filled with Ledermix, Triamcinolone, and Demeclocycline, respectively, and replanted after 60 min dry time. After 4 months, the dogs were sacrificed and the roots were examined histologically for type of healing (favorable or unfavorable) and remaining root diameter. The groups treated with Ledermix, Triamcinolone and Demeclocycline had statistically significantly more favorable healing (75.8%; 69.8%; 52.4%) and more remaining root structure (5.59; 5.48; 5.09) than the group filled with GP and sealer (positive control) (0; 1.15). Corticosteroids were as effective as Ledermix at inhibiting external root resorption.
再植牙的预后取决于几个因素，其中最重要的是口腔外干燥时间的长短。研究表明，干燥60分钟后，预计会发生牙根吸收。已证明，立即在根管内放置含曲安奈德（皮质类固醇）和强力霉素（四环素）的Ledermix糊剂可抑制延长干燥时间后的牙根吸收。然而，Ledermix中的四环素可能会导致牙齿变色。为了评估皮质类固醇和四环素对延长口腔外干燥时间后牙根外部吸收的个体影响。从4只比格犬中拔出69颗前磨牙牙根，并用镍钛锉进行预备。第1组（阴性对照）用牙胶尖和封闭剂根管充填后立即再植；第2组（阳性对照）用牙胶尖和封闭剂根管充填，干燥60分钟后再植；第3 - 5组的根管分别用Ledermix、曲安奈德和强力霉素充填，干燥60分钟后再植。4个月后，处死犬只，对牙根进行组织学检查，观察愈合类型（良好或不良）和剩余牙根直径。与用牙胶尖和封闭剂充填的组（阳性对照）（0；1.15）相比，用Ledermix、曲安奈德和强力霉素治疗的组在统计学上有更有利的愈合（75.8%；69.8%；52.4%）和更多的剩余牙根结构（5.59；5.48；5.09）。皮质类固醇在抑制牙根外部吸收方面与Ledermix一样有效。
